Anti-IgE: beyond asthma
نویسنده
چکیده
Omalizumab (anti-IgE ab) is a recombinant humanized monoclonal antibody (rhuMAb-E25) developed by immunizing mice with human IgE. Then, a monoclonal antibody was selected that recognizes IgE at the same site as the highaffinity receptor for IgE (FcεRI). Omalizumab is the only Mab to date that has been found to be effective and approved by both the FDA and European Medicines Agency (EMA) for the treatment of difficult allergic asthma.
منابع مشابه
Itraconazole as “bridge therapy” to anti-IgE in patients with severe asthma with fungal sensitization
Background Sensitization to fungi has been reported to play an important role in a particular phenotype of severe asthma, the so called severe asthma with fungal sensitization (SAFS), characterized by high levels of total IgE, which may be an obstacle to anti-IgE therapy. A few studies showed the benefit of antifungal therapy in improving the quality of life of patients with SAFS associated to ...
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IgE has long been known as a therapeutic target for allergic disease, but the difficulty has been in selecting agents that don't trigger cross linkage of IgE when bound to its high affinity receptor (FceR1) on mast cells and basophils. By "designing" a monoclonal antibody (mAb) which targets that part of IgE that binds to that binds to the a-chain of FceR1, the allergic cascade can be effective...
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Sensitisation to fungi has been reported to play an important role in a particular phenotype of severe asthma, the so-called severe asthma with fungal sensitisation, characterised by high levels of total IgE, which may be an obstacle to anti-IgE therapy. We describe here the case of a polysensitised woman with refractory asthma, sensitised to Aspergillus fumigatus with high total IgE values (17...
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تاریخ انتشار 2012